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BioInspired Materials

The Center for Bio-Inspired Nanomaterials at MSU is an multidisciplinary research and education center focused on utilizing our fundamental understanding of the formation and hierarchical construction of biological materials such as viruses, cells, and biominerals (bones, teeth, seashells, etc.). One extension of this fundamental work is the utilization of biological macromolecular assemblies as templates for the construction of novel functional nano-materials. However, the goal of the center is to encompass the study of the wide range of materials, beyond those of biological origin, to achieve unique physical properties by design.

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Montana State University

Division of Graduate Education

Molecular Biosciences Program

P.O. Box 172580
Bozeman, MT 59717-2580

(406) 994-6652 mbprogram@montana.edu

 

Molecular BIOSciences |> BioInspired Materials
|> Faculty |> Ross P Carlson, Ph. D

Metabolic Network Analysis and Engineering; Antibiofilm Surface Coating Strategies

Current Research

I am using a combination of theoretical and experimental techniques to elucidate microbial biochemical network usage strategies as a response to environmental stresses. The goal is to understand what stresses have influenced the evolution of an organism and to determine what adaptations the organism has made to remain competitive. The knowledge will be used to engineer microbial strains for biotechnological processes and for interpreting proteomic and genomic data.

Many microbes construct complex 3-dimentional, polymer encapsulated communities known as biofilms. The physical and phenotypic properties of these biofilm communities make them very resistant to common antimicrobial strategies like antibiotics. Biofilms are major problems in a number of industries including the medical field. It has been estimated that 80% of human infections are related to biofilms. I am developing surface coating strategies in collaboration with the Center for Biofilm Engineering to inhibit or to prevent the formation of biofilms on surfaces like those found on medically implanted devices.

Recent Publications

Carlson, R.P., Taffs, R., Davison, W.M., Stewart, P.S. (2008) Anti-biofilm properties of chitosan coated surfaces. Journal of Biomaterials Science: Polymer Edition. 19: 1035-1046.

Carlson, R.P. (2007) Metabolic systems cost-benefit analysis for interpreting network structure and regulation. Bioinformatics. 23: 1258-1264.

Carlson, R., Srienc, F. (2006) Gene dosage effects on polyhydroxyalkanoate production in Saccharomyces cerevisiae. Journal of Biotechnology. 124: 561-573.

Carlson, R., Wlaschin, A., Srienc, F. (2005) Kinetic studies and biochemical pathway analysis of anaerobic poly(R)-3-hydroxybutyric acid synthesis in Escherichia coli. Applied and Environmental Microbiology. 71: 713-720.

Carlson, R., Srienc, F. (2004) Fundamental Escherichia coli biochemical pathways for biomass and maintenance energy production: Identification of pathways. Biotechnology and Bioengineering. 85(1): 1-19.

Carlson, R., Srienc, F. (2004) Fundamental Escherichia coli biochemical pathways for biomass and maintenance energy production: Creation of overall flux states. Biotechnology and Bioengineering. 86(2): 149-162.

Carlson, R., Fell, D., Srienc, F. (2002) Metabolic pathway analysis of a recombinant yeast for rational strain development. Biotechnology and Bioengineering. 79(2): 121-134.


 
Ross P Carlson, Ph. D


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Updated: 8/16/08
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