We build genetically encoded fluorescent sensors that enable neuroscientists to measure processes in living systems.
Currently we are involved in a large, international collaboration to build the next generation of fluorescent voltage sensors. http://www.fpsensor.net
We are also actively collaborating with Montana Molecular, a private biotech company here in Bozeman to create a new series of fluorescent probes for high throughput screens http://www.montanamolecular.com/
We collaborate with the Rebane lab in physics to create the next generation of fluorescent proteins for 2 photon imaging applications. http://www.physics.montana.edu/faculty/rebane/grouphome.htm
Our research group is small, fun, and dedicated to trying things in the lab other people wouldn't.
Sheridan, D. L., and Hughes, T. E. (2004). A faster way to make GFP-based biosensors: two new transposons for creating multicolored libraries of fluorescent fusion proteins. BMC Biotechnology 4, 1
Boyd, C., Hughes, T., Pypaert, M. and Novick, P. (2004) Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p. J. Cell. Biol. 167, 889-901.
Giraldez, T., Hughes, T.E., Sigworth, F.J. (2005) Generation of functional fluorescent BK channels by random insertion of GFP variants. Journal of General Physiology. 126, 429-438.
T. Rex, J. A. Peet, E.M. Surace, P. D. Calvert, S. S. Nikonov, A. L. Lyubarsky, E. Bendo, T. Hughes, E.N. Pugh, Jr., and J. Bennett. (2005). The distribution, concentration, and toxicity of EGFP in retinal cells after genomic or somatic (virus-mediated) gene transfer. Molecular Vision 11, 1236-45.
Drobizhev, M., Makarov, N.S., Hughes, T., and Rebane, A. (2007). Resonance enhancement of two-photon absorption in fluorescent proteins. J Phys Chem B 111, 14051-14054.