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Neuroscience is the study of the structure and function of nervous systems. It is a highly interdisciplinary field that spans many levels of analysis, ranging from molecular and cellular to cognition and behavior. It is a field that incorporates a wide range of disciplines including molecular biology, biophysics, physiology, anatomy, psychology, engineering, mathematics, computer science and medicine.

The Neuroscience group at MSU spans many of these levels and disciplines. The faculty employ a wide array of experimental and theoretical approaches to study the nervous systems of organisms ranging from invertebrates to non-human primates, and to investigate functions ranging from neuronal excitability and neural development to information processing, perception and cognition.


Contact Us

Montana State University

Division of Graduate Education

Molecular Biosciences Program

P.O. Box 172580
Bozeman, MT 59717-2580

(406) 994-6652


Molecular BIOSciences |> Neuroscience
|> Faculty |> Thomas E Hughes, Ph. D

Building Genetically encoded biosensors

Current Research

We build genetically encoded fluorescent sensors that enable neuroscientists to measure processes in living systems.

Currently we are involved in a large, international collaboration to build the next generation of fluorescent voltage sensors.

We are also actively collaborating with Montana Molecular, a private biotech company here in Bozeman to create a new series of fluorescent probes for high throughput screens

We collaborate with the Rebane lab in physics to create the next generation of fluorescent proteins for 2 photon imaging applications.

Our research group is small, fun, and dedicated to trying things in the lab other people wouldn't.

Recent Publications

Sheridan, D. L., and Hughes, T. E. (2004). A faster way to make GFP-based biosensors: two new transposons for creating multicolored libraries of fluorescent fusion proteins. BMC Biotechnology 4, 1

Boyd, C., Hughes, T., Pypaert, M. and Novick, P. (2004) Vesicles carry most exocyst subunits to exocytic sites marked by the remaining two subunits, Sec3p and Exo70p. J. Cell. Biol. 167, 889-901.

Giraldez, T., Hughes, T.E., Sigworth, F.J. (2005) Generation of functional fluorescent BK channels by random insertion of GFP variants. Journal of General Physiology. 126, 429-438.

T. Rex, J. A. Peet, E.M. Surace, P. D. Calvert, S. S. Nikonov, A. L. Lyubarsky, E. Bendo, T. Hughes, E.N. Pugh, Jr., and J. Bennett. (2005). The distribution, concentration, and toxicity of EGFP in retinal cells after genomic or somatic (virus-mediated) gene transfer. Molecular Vision 11, 1236-45.

Drobizhev, M., Makarov, N.S., Hughes, T., and Rebane, A. (2007). Resonance enhancement of two-photon absorption in fluorescent proteins. J Phys Chem B 111, 14051-14054.

Thomas E Hughes, Ph. D

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Updated: 8/16/08


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